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Macular Degeneration
Macular Degeneration: Science and Medicine in Practice provides a unique overview of current thinking in the pathogenesis, incidence and treatment of AMD. It includes, for the first time, a synthesis of the views of the world's leading scientists and practitioners regarding retinal biology, basic mechanisms, clinical and pathogenetic processes, and rational approaches to intervention.
Machine learning for neurodegenerative disorders : advancements and applications
Explores the application of machine learning to the understanding, early diagnosis, and management of neurodegenerative disorders. With a specific focus on its role in ongoing clinical trials, the book covers essential topics such as data collection, pre-processing, feature extraction, model development, and validation techniques. It delves into the applications of neuroimaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) in the diagnosis and understanding of neurodegenerative disorders. Additionally, the book examines various machine-learning algorithms employed for biomarker discovery in neurodegenerative disorders. It highlights the role of neuroinformatics and big data analysis in advancing the understanding and management of neurodegenerative disorders. Furthermore, the book reviews future prospects and presents the ethical considerations and regulatory challenges associated with implementing machine learning approaches in the diagnosis, treatment, and prevention of neurodegenerative disorders.
Liquid Culture Systems for in vitro Plant Propagation
High-efficiency micropropagation, with relatively low labour costs, has been demonstrated in this unique book detailing liquid media systems for plant tissue culture. World authorities contribute seminal papers together with papers from researchers across Europe This book is essential reading for all those in commercial micropropagation labs, as well as researchers worldwide who are keen to improve propagation techniques and lower economic costs of production.
Le Distilbène trente ans après : Les enfants des 2èmes et 3èmes générations = Distilbene thirty years later : The children of the 2nd and 3rd generations
The various consequences on the anatomy and physiology of the female genitalia, as well as male, of children exposed in utero are reviewed. The impact on girls is greater than on boys: modification of the uterine cervix, reduction in the volume of the uterus with its consequences on fertility and the progress of pregnancies, risk of cancer of the vagina and the cervix. . The potential repercussions on the third generation are analyzed from experimental studies. Finally, the medico-legal implication is studied from the various trials that took place in the United States and from the first French trial that took place in Nanterre in November 2003. This work is the result of the collaboration of several experts recognized for their competence in this field. It will be of interest to all obstetrician gynecologists, urologists, but also public health physicians and midwives.
Claytons basic pharmacology for nurses
Helps you understand the principles of pharmacology and apply them to nursing practice. Known for its practical application of the nursing process to drugs and disorders, this book explains how to make informed decisions about drug therapy, educate patients, and administer medications. This edition adds new Next Generation NCLEX® (NGN)-style case studies and questions to prepare you for the critical thinking questions on the NGN exam. Concise and easy to use, this text teaches the basics of medication administration and drug actions.
Chromatin and Disease
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics.
Chemical principles of nanoengineering
Nanomaterials, which possess at least one dimension lower than 100 nanometers, are increasingly at the forefront of technological and chemical innovation. The properties of these uniquely minute materials give them distinctive applications across a huge range of industries and research fields. It is therefore critical that the next generation of engineers and materials scientists understand these materials, their chemical properties, and how they form bonds
Chemical Biology of Neurodegeneration : A Molecular Approach
This book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered.
Cartilage Repair Strategies
Cartilage Repair Strategies is a comprehensive update of the present state of cartilage repair and regeneration. The information in this volume addresses what methods are effective, what methods are safe, and what methods will lead to an alteration in the short history of articular cartilage injury repair. Contributors present examinations of a variety of topics including the structure and function of articular cartilage, the evaluation of cartilage repair techniques, and the latest cartilage sensitive imaging techniques.
Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches
The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering.
Carbohydrate-based therapeutics
Explores new frontiers in carbohydrate-based therapeutic applications, utilizing a unique approach by providing a detailed background of diseases coupled with subsequent carbohydrate-based therapies. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and a broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure– activity relationship, and impact on health and diseases. The text also discusses newer topics like nanoparticles, material science, and tissue generation.
Cancer immunotherapy : Methods and protocols
Details multiple areas of new and emerging methods to develop the next generation of immunotherapy treatments. Chapters guide readers through analysis and characterisation of the interactions between tumour and immune cells, and cell engineering tools for cancer treatment, to provide a unique and compelling set of techniques instrumental to work with, and engineer, immune cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Brown and Mulholland’s drug calculations
A realistic practice problems and unique "proof" step in the answer key that allows you to double-check your answers to avoid medication errors. This edition continues to promote critical thinking, clinical judgment, and patient safety with respect to accurate drug dosages. Helpful worksheets, assessment tests, and Clinical Alerts call attention to situations in actual practice that have resulted in drug errors — giving you extensive hands-on practice for the Next Generation NCLEX® and beyond.
Breathing, feeding, and neuroprotection
New findings in brain research are being revealed on an almost daily basis, and the focus of this book is the fields of breathing, neuroprotection, and higher brain functions. An unresolved issue within respiration research and hence a topic of much interest is Where and how respiratory rhythm is generated in the brainstem, detailed analysis of which is presented herein. Chapters on neuroprotection examine the functional significance of the blood – brain barrier as an interface of blood and the central nervous system; other chapters look at health and disease in relation to the hypothalamic and limbic systems. In addition to animal experiments, research on the human brain is included, with a focus on the recently developed EEG/dipole tracing method. This book will be an invaluable reference for researchers in neuroscience and related fields.
Bone and Cartilage Engineering
Bone and Cartilage Engineering presents the theory and practice of cell-based regeneration of skeletal defects. Much of the focus is on the importance of the cell biological and biomaterial aspects for engineering a clinically relevant device. The basic key techniques for optimal engineering outcomes including cell and organ culture, biomaterial development, and bioreactor use are described in detail and highlighted by multiple figures.
Biomarkers for alzheimer’s disease drug development
Aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Bioinformatics and systems biology : Collaborative research and resources
Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them. The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.
Bioimaging in Neurodegeneration
offers both the physician and researcher a critical survey of the best new technologies for studying neurodegeneration, as well as describing their optimal use in the diagnosis and treatment of specific neurodegenerative diseases
Beyond global food supply chains : Crisis, disruption, regeneration
Through a set of incisive essays, this incredibly timely book shows how much the COVID-19 pandemic has exposed both vulnerabilities and opportunities - for (racial) capitalism and its discontents alike to intervene in food supply chains. A most welcome publication! This book takes the upheaval of the global COVID-19 pandemic as a springboard from which to interrogate a larger set of structural, environmental and political fault lines running through the global food system. In a context in which disruptions to the production, distribution, and consumption of food are figured as exceptions to the smooth, just-in-time efficiencies of global supply chains, these essays reveal the global food system as one that is inherently disruptive of human lives and flourishing, and of relationships between people, places, and environments. The pandemic thus represents a particular, acute moment of disruption, offering a lens on a deeper, longer set of systemic processes, and shining new light on transformational possibilities.
Axonal branching and recovery of coordinated muscle activity after transsection of the facial nerve in adult rats
Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets
