Dr. Manfred Küpper

مانفريد كوبر

Dr. Manfred Küpper


Experience

Scientific Contributions

 

Küpper & R. Hallak;

 

From Therapeutic Drug Monitoring To Drug Management: IMPDH Activity As Novel Surrogate Marker For Dose Adjustment Of Mycophenolate In Immunosuppressive Therapy

Journal of the Syrian Clinical Laboratory Association,

 

Kahlous NA, Bawarish MAM, Sarhan MA, Küpper M, Hasaba A, Rajab M

Using Chemoinformatics, Bioinformatics, and Bioassay to Predict and Explain the Antibacterial Activity of Nonantibiotic Food and Drug Administration Drugs.

Assay Drug Dev Technol. 2017 Apr;15(3):89-105.

 

Rath, M. Küpper;

Pharmacokinetics and Pharmacodynamics of Mycophenolate in Patients After Renal Transplantation; Renal Transplantation - Updates and Advances,

Intech Open Access Publisher (2011) ISBN: 978-953-51-0173-4

(http://www.intechopen.com/books/renal-transplantation-updates-and-advances)

Rath, M. Küpper;

Comparison of Inosine-Monophosphate-Dehydrogenase (IMPDH) Activity in Patients With Enteric-Coated Mycophenolate-Sodium (EC-MPS) or Mycophenolate Mofetil (MMF) After Renal Transplantation; Transplantation Proceedings, 2009 Jul-Aug;41(6):2524-8.

 

El-Maarri, M. Küpper, J. Oldenburg, J. Walter;

Quantitative DNA-Methylation Analysis by the Bisulfite Conversion Method

PCR Technology: Current Innovations 2nd ed./ edited by Th. Weissensteiner, H. Griffin, A. Griffin, CRC Press (2004), ISBN 0-8493-1184-5

 

Wessendorf, B. Fritz, M. Kuepper, G. Wrobel, M. Nessling, S. Lampel, D. Goettel, S. Joos, T. Hopman, R. Weber, H. Döhner, M. Bentz, C. Schwaenen, P. Lichter;

Automated screening for Genomic Imbalances using matrix-based Comparative Genomic Hybridization (Matrix-CGH); Laboratory Investigation 82(1): 47-60 (2002)

 

Küpper, S. Joos, F. v. Bonin, H. Daus, M. Pfreundschuh, P. Lichter, L. Trümper;

MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: Evidence from single cell PCR and molecular cytogenetic studies; British Journal of Hematol. 112 (3): 768-775 (2001)

 

Joos, M. Küpper, S. Ohl, F. v. Bonin, M. Bentz, P. Marynen, P. Möller, M. Pfreundschuh, L. Trümper, P. Lichter;

Genetic evidence for similar chromosomal imbalances in Hodgkin and Reed-Sternberg cells and primary mediastinal B-cell lymphoma; Cancer Research 60: 549-552 (2000)

 

Küpper,M et al.; Single cell PCR for the analysis of Hodgkin's disease: Four years later; Annals of Oncology 7 (Suppl. 4): S35-S39 (1996)

 

Küpper,M et al.; Characterization of Protein Kinase CK2 Protein Subunits and p53 in F9 Teratocarcinoma Cells in the Absence and Presence of Cisplatin; Cell.Mol.Biol.Res. 40 (5-6): 587-592 (1994


Education
01.11.98 – 31.12.00 German Cancer Research Centre (DKFZ), Heidelberg/ Germany Dept. Organization of Complex Genomes, Prof. Dr. P. Lichter Postdoctoral Fellow  Substantial contribution to the development of the matrix-CGH DNA-chip technology and the respective chemistry (DNA-probe labelling, coating of the chip-surface, hybridization conditions)