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Mannitol : Chemistry, Uses and Potential Side Effects
Presents topical research in the study of the chemistry, uses and potential side effects of mannitol. Topics discussed include the utilization and production of D-mannitol by bacteria; concentration of mannitol and other soluble carbohydrates in the crustose lichen rhizocarpon geographicum; disease-related changes and mannitols use for clinical disorders; use of mannitol in thermal energy storage applications; and chiral phosphorous ligands derived from D-mannitol.
Managing Your Headaches
Frequent headaches seriously affect the lives of millions of sufferers. The result can be lost productivity and income, restrict activity, lower self-esteem, and even social isolation. For many, it takes years to find the appropriate medication to manage your headaches effectively. In Managing Your Headaches, Mark and Leah Green and John Rothrock explain what information you should record for your physician, what a physician is looking for in a neurological examination, and what you should (and should not) do to reduce the frequency and severity of your headaches. They discuss the effects of stress, psychological factors, possible food triggers, and environmental risk factors. The authors explain the symptoms of migraine, cluster, and tension-type headaches as well as less common types. They address common concerns and misconceptions and explain current knowledge about headache causes in understandable terms. The newest, most effective medications and their possible side effects are evaluated. The authors also explain how to prevent rebound headaches from over-medications and how non-medical treatments can be of value. Managing Your Headaches will tell you what you need to know to better control your headaches. Armed with the information in this book, you can be aware of the latest treatment options and can have more productive, informed discussions with your physician.
Cardiac drug therapy
Cardiac Drug Therapy, 7th ed., addresses the pharmacology and therapeutic application of drugs used to treat heart diseases and hypertension. Additions and updates to the sixth edition include six new chapters on current controversies in cardiac drug therapy such as the beta blocker issue many cardiologists are presently grappling with. The book provides practical advice on how to manage cardiac diseases and addresses the choice of one particular cardiac agent vs. another. In addition to providing core knowledge in cardiovascular therapeutics, the text assists in resolving some of the issues surrounding cardiac drugs. Cardiac Drug Therapy provides practical information including properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Bisphosphonates in medical practice : Actions - side effects - indications - strategies
Clinical osteology is now an independent specialty which nevertheless encompasses all branches of medicine and effects each and every one of us: Bone is Every Body´s Business: This book has been designed as an up to date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment. It is intended for doctors who seek precise information on bisphosphonates in medical practice to enable them to treat patients with disorders of bone or better still to avoid their occurrence .
Bioinformatics tools for pharmaceutical drug product development
Presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. And include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall.
Analysis file of drug-induced lung injury : expert opinion for analysis of big data
Describes the pathologic conditions of drug-induced lung injuries, monitoring strategies, and guides on how to interpret the evidence. It also dives into particular drugs that caused the disorder, such as EGFR inhibitors, anti-EGFR antibodies, mTOR inhibitors, proteasome inhibitors, immune checkpoint inhibitors, neoangiogenesis inhibitors, and other molecular targeted drugs. It outlines the analysis and interpretation of the post-marketing survey on surveillance of each drug for inducing pulmonary lesions presenting diffuse haziness. The data and analysis from this survey are valuable since a guideline is yet to be established due to limited clinical evidence and cases. As new drugs are developed, establishing treatment and event management is crucial.
An introduction to pharmacovigilance ; 2nd ed.
Designed to aid the rapid understanding of the key principles of pharmacovigilance. Packed full of examples illustrating drug safety issues it not only covers the processes involved, but the regulatory aspects and ethical and societal considerations of pharmacovigilance. Covering the basics step-by-step, this book is perfect for beginners and is essential reading for those new to drug safety departments and pharmaceutical medicine students. The second edition is thoroughly revised and updated throughout and includes a new chapter on clinical aspects of pharmacovigilance.
Advanced Issue Resolution in Safety Pharmacology
Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues.
Local Anaesthesia in Dentistry
A comprehensive guide to the use of local anaesthesia in dentistry that will meet the needs of both students and dental practitioners. It provides the reader with ample background information on the origin of pain and the pharmacology of anaesthetics, and describes the anatomy of the trigeminal nerve in detail. Subsequent chapters cover key are as such as general practical aspects, local anesthaesia in the upper and the lower jaw, the use of local anaesthetics in children, local and systematic complications, and the prevention of side effects. Patients at particular risk of adverse effects are identified and attention drawn to significant legal aspects.
A Risk-Benefit Perspective on Early Customer Integration
Customer integration in the early innovation phase has been considered the method of choice in theory and practice. Growing experience with the concept has shown unexpected side effects that may even outweigh its recognized advantages. Therefore, management needs to be able to assess in advance whether the involvement of customers will add overall value to each particular innovation project. To support but not to replace the final managerial decision, a mathematical formula is developed. It can be applied to all kinds of process structures, takes into account the risks and benefits contingent on a company's situation as well as risk-reducing and benefit-increasing measures and translates them into numerical values. The resulting figure indicates the prospective value of customer integration in a specific project.
