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الصفحة 31
الصفحة 31
Artificial intelligence based cancer nanomedicine : Diagnostics, therapeutics and bioethics
Nanomedicine is evolving with novel drug formulations devised for multifunctional approaches towards diagnostics ad therapeutics. Nanomedicine-based drug therapy is normally explored at a fixed dose. The drug action is time-dependent, dose-dependent and patient-specific. To overcome challenges of nanomedicine testing, artificial intelligence (AI) serves as a helping tool for optimizing the drug and dose parameters. Real time conversions between these two features enables upgradation of patient data acquisition and improved design of nanomaterials. In this scenario, AI-based pattern analysis and algorithms models can greatly improve accuracy of diagnostics and therapeutics.
Arthroscopic rotator cuff surgery : A practical approach to management
The timely book answers key questions raised at instructional courses, such as how to convert from mini-open repair to all arthroscopic repair. The fundamentals, including patient positioning, suture anchor options, and knot tying, are covered in addition to state-of-the-art techniques.
Arthropod Diversity and Conservation
Despite their enormous bulk and complexity of architecture, plants make up only around a quarter of a million of the 8 million or so species on Earth. The major components of biodiversity, instead, are the smaller, largely unseen, silent majority of invertebrates – most of which are arthropods. Vertebrates, a mere blip on the biotic horizon, are elevated in importance in the bigger scheme of things only by the human psyche. This collection of more than 30 peer-reviewed papers focuses on the diversity and conservation of arthropods, whose species inhabit virtually every recess and plane – and feature somewhere in virtually every food web – on the planet. Highlighting issues ranging from large-scale disturbance to local management, and from spatial heterogeneity to temporal patterns, these papers reflect some of the most exciting new research taking place today – and in some of the most biodiverse corners of the planet.
Arterial Grafting for Coronary Artery Bypass Surgery
The second edition of this book provides updated knowledge about the biological characteristics and clinical use of arterial grafts for coronary artery bypass surgery. The reader will find first-hand information on arterial grafts as well as vein grafts with regard to biological characteristics, clinical use including off-pump coronary bypass grafting surgery, results, and future developments. Written by world-renowned cardiac surgeons and cardiovascular research scientists working in this area.
Arrhythmogenic RV cardiomyopathy / dysplasia : Recent advances
This book covers all aspects (biological, pathological, genetic, clinical and therapeutical) of arrhythmogenic right ventricular cardiomyopathy/dysplasia, a recent cardiomyopathy which represents a very high risk of sudden death in the young and in athletes. The monograph presents the results of 5-year research program on ARVC/D supported by grants of both the European Commission and the NIH, which enabled the discovery of seven disease-causing genes, thus opening new avenues for the early identification of affected patients and for sudden death prevention.
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Arid Dune Ecosystems: The Nizzana Sands in the Negev Desert
Sand dune dynamics plays a key role in many arid deserts. This volume provides a synthesis of a specific sand dune ecosystem, the Nizzana site in the Negev Desert. Describing its climate and geophysical/geochemical properties of soils, geological history, flora and fauna, and past/present land-use patterns, it elucidates ecological and geomorphological processes and their interrelations, based on long-term monitoring, in situ experiments and satellite imagery. Particular attention is drawn to the impact of the topsoil biological crust in controlling water availability at local/regional scales. The interdisciplinary approach adopted in this case study offers a good example of a highly complex and dynamic system, which could easily be applied to other sandy ecosystems.
Area-wide control of insect pests : From research to field implementation
This new textbook on area-wide control of insect pests collates a series of selected papers that attempts to address various funda- mental components of AW-IPM, e.g. the importance of relevant problem-solving research, the need for essential baseline data, thesignificanceofadequatetoolsforappropri-atecontrolstrategies,andthevalueofpilottri- als, etc.
Aquatic medicinal plants
The use of medicinal plants in herbal and modern medicine has gained popularity over the last few decades due to consumers taking more natural approaches to medicine. Aquatic medicinal plants are rich in bioactive compounds and demonstrate various commercial, nutraceutical, and biological applications. Aquatic Medicinal Plants offers the reader a wealth of information on uses of bioactive components of these plants, along with crucial references, and explains their traditional uses, phytochemistry, and pharmacological properties.
Aquatic Biodiversity II : The Diversity of Aquatic Ecosystems
The present book comprises a unique collection of primary research papers spanning a wide range of topics in aquatic biodiversity studies, and including a first global assessment of specific diversity of freshwater animals. The book also presents a section on the interaction between scientists and science policy managers
Aquaponics Food Production Systems : Combined Aquaculture and Hydroponic Production Technologies for the Future
This book, written by world experts in aquaponics and related technologies, provides the authoritative and comprehensive overview of the key aquaculture and hydroponic and other integrated systems, socio-economic and environmental aspects. Aquaponic systems, which combine aquaculture and vegetable food production offer alternative technology solutions for a world that is increasingly under stress through population growth, urbanisation, water shortages, land and soil degradation, environmental pollution, world hunger and climate change.
Aquaculture microbiology
Details techniques involved to study aquatic pathogens that cause infections, especially in fish. Chapters guide readers through a wide range of basic and advanced methods, viral and fungal pathogens, probiotic bacteria, treatment of pathogens using seaweed extract, medicinal plant extracts, and actinomycetes.
Aquaculture in the Ecosystem
This book provides a scientific forecast of the development in aquaculture with a focus on the environmental, technological, social and economic constraints that need to be resolved to ensure sustainable development of the industry and allow the industry to be able to feed healthy seafood products to the future generations. The chapters included discuss the most critical bottlenecks of the development encompassing subjects of understanding the environmental impacts, the current state-of-art in monitoring programs and in coastal zone management, the important interactions between wild and cultured organisms including release of non-native species into the wild, the current trends within the development of aquafeeds along with human health aspects as well as the political, socio-economic and economic trends within the industry including a chapter on approaches taken by Non Governmental Organisations (NGOs) to aquaculture. Finally the last chapter provides different future scenarios of the industry based on the identified bottlenecks.
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use.
Approche pratique de la couverture des pertes de substance cutanée de la main et des doigts = Practical Approach to Covering Skin Losses from the Hand and Fingers
This book is neither a summary nor an encyclopedia devoted to the treatment of loss of skin substance in the hand. There are currently excellent books that can serve as a reference, at any time, for the treatment of any skin defect, of the hand ... or elsewhere. We wanted a completely different perspective on trauma management open by hand, while respecting the spirit of the “Practical Approach” collection directed by Christian Fontaine: a simple presentation diagram, relatively stereotypical, a rich and varied iconography, tips and tricks, in short, an anthology of technical details and answers to the most common questions about hand flap surgery.
Approaches to the purification, analysis and characterization of antibody-based therapeutics
Provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.
Applied therapeutics : The clinical use of drugs
"Continually revised and updated for 50 years, Applied Therapeutics: The Clinical Use of Drugs is the gold standard for patient centered drug therapeutics. With its acclaimed case-based approach, it promotes mastery and application of the fundamentals of drug therapeutics. Featuring contributions from more than 200 experienced clinicians, every chapter reflects our ever-changing knowledge of drugs and the application of this knowledge to the individualized therapy of patients. As students progress from the General Principles section to chapters on specific diseases, they will benefit from practical problem-solving techniques that help devise effective evidence-based drug treatment plans"
Applied Spatial Data Analysis with R
Applied Spatial Data Analysis with R is divided into two basic parts, the first presenting R packages, functions, classes and methods for handling spatial data, The second part showcases more specialised kinds of spatial data analysis, including spatial point pattern analysis, interpolation and geostatistics, areal data analysis and disease mapping.
Applied Physiology in Intensive Care Medicine
A series of short papers published in Intensive Care Medicine since 2002 under the heading Physiologic Notes attempts to capture the essence of the physiologic perspectives that underpin both our understanding of disease and response to therapy. Tis present volume combines the complete list of these Physiologic Notes up until July 2006 with the ass o ciated review articles over the same in terval that also address edthese central issues.
