Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Acute coronary syndrome : Multidisciplinary and pathway-based approach
Acute coronary syndrome (ACS) affects millions of patients annually and requires immediate diagnosis and therapy. This practical algorithm-based handbook addresses the diagnosis and treatment of these patients and is designed for the medical personnel involved in the triage and management of ACS patients.
Actualités en rééducation des maladies neuro-musculaires de ladulte = News in rehabilitation of neuro-muscular diseases in adults
Neuro-muscular diseases include congenital or acquired pathologies of the muscle and the peripheral nerve. This book covers all the care of the adult patient with such a condition.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Actin Monomer Binding Proteins
The actin cytoskeleton plays a central role in many cellular processes including cell motility, cytokinesis, endocytosis and phagocytosis. The structure and dynamics of the actin cytoskeleton is regulated by a large number of proteins that interact with monomeric and/or filamentous actin. Actin monomer binding proteins provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin.
Acceleration and Improvement of Protein Identification by Mass Spectrometry
this book is presenting a review of basic proteomic techniques. The second part of the book is related to the novel high throughput protein identification technique called the 'molecular scanner'
Accelerated Partial Breast Irradiation : Techniques and Clinical Implementation
Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text will be a concise handbook designed to assist the clinician in the implementation of APBI.
Abord clinique en urologie = Clinical approach in urology
Seduced by the idea of commenting on the clinical experience they have acquired during their career, the authors have deliberately approached their specialty by describing the symptoms that give the chapters their titles. They nevertheless described the differential diagnoses, the diseases involved and the treatments. After a chapter devoted to the examination of the patient, including the detours of the interrogation, back pain or scrotal pain are analyzed. The authors then turned to voiding disorders and their causes. The peculiarities of hematuria, depending on their level of origin, are described and commented on. The semiology of tumor masses is carefully detailed and, conversely, the problem of prostate cancer screening by PSA is dealt with in a separate chapter. Erectile dysfunction and penile diseases are the last chapters. In the line of the “Clinical approach” collection, this manual is easy to consult thanks to a detailed index, easy to understand because it is written in clear language and, moreover, well illustrated (21 diagrams and 2 tables). In this little book, the authors have approached urology from a perspective close to how patients feel.
Abord Clinique en Obstétrique = Clinical approach in Obstetrics
This book aims to clarify and develop the particularities of the clinical examination in obstetrics; it deliberately excludes childbirth and the aftermath of childbirth.
Abord clinique des urgences traumatiques au cabinet du généraliste = Clinical approach to traumatic emergencies in the general practitioner's office
Cet ouvrage a été conçu comme une aide pour le médecin généraliste, confronté quotidiennement à la pathologie traumatique. Les deux auteurs, urgentistes expérimentés, apportent des réponses claires, concises et pratiques aux problèmes que posent les lésions traumatiques. Des gestes simples, un abord clinique détaillé, la nécessité de recourir ou non à des examens complémentaires ou à un avis spécialisé sont ici expliqués et justifiés. Le style est précis, concis, et un lexique complète les définitions et les matériels cités dans le texte. Les auteurs se sont entourés des avis de généralistes et de spécialistes pour définir des conduites à tenir simples et compatibles avec les nécessités du terrain.
Abord Clinique des Urgences au Domicile du Patient = Emergency Clinic at the Patient's Home
The general practitioner finds himself alone in the face of difficult and urgent situations. Her internship years taught her to work with the nursing team. At the patient's home, he must act alone with "the means at hand". To have known these difficulties, we conceived this work: it is intended to be a simple, effective and complete help. It sums up what we have learned from the “field”. It complies with scientific recommendations.
Abord clinique des malades de lalcool : En médecine générale = Clinical approach to patients with alcoholism : In general medicine
Les médecins généralistes sont destinataires d’un grand nombre d’informations sur l’alcool, son usage et ses conséquences pathologiques immédiates ou potentielles. Ces connaissances, émanant de médecins le plus souvent hospitaliers et spécialisés, ont conduit à des recommandations destinées à guider les médecins généralistes dans le repérage des malades de l’alcool et leur prise en charge thérapeutique. Cependant, la pertinence et l’applicabilité de la plupart de ces recommandations sont peu ou mal évaluées dans la pratique de la médecine générale. De ce fait, les médecins généralistes, parfois à l’encontre des recommandations, sont amenés à élaborer des concepts et des pratiques propres à leur clientèle et à leurs conditions de travail. L’originalité de ce livre vient de la confrontation des connaissances et des pratiques de deux médecins, soignant des malades de l’alcool dans des structures différentes.
Abl Family Kinases in Development and Disease
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.
A Sea Change: The Exclusive Economic Zone and Governance Institutions for Living Marine Resources
A Sea Change in a Changing Sea The oceans, seas and coastal areas encompass over 70% of the earth’s surface. They are a critical driver of the earth’s hydrologic cycle and climate system, important for c- merce, transport, and tourism, a source of economically important living marine resources, minerals such as hydrocarbons, as well as new pharmaceutical compounds. The marine environment provides essential habitats for thousands of marine living 1 2 resources, which in turn contribute significantly to global food security, employment, 3 and trade. Overall, the sea’s contribution to human welfare, in terms of market and non-market resources and environmental services, has been estimated at US$21 trillion/year (Costanza, 2000). However, despite the importance of the ocean realm to humans, there is a growing sense that human impacts are destabilizing this system. Some experts believe that current fishing levels are approaching or exceeding the total 4 productivity of the ocean ecosystem (National Research Council, 1999).
A Life Course Perspective on Health Trajectories and Transitions
This book examines health trajectories and health transitions at different stages of the life course, including childhood, adulthood and later life. It provides findings that assess the role of biological and social transitions on health status over time. The essays examine a wide range of health issues, including the consequences of military service on body mass index, childhood obesity and cardiovascular health, socio-economic inequalities in preventive health care use, depression and anxiety during the child rearing period, health trajectories and transitions in people with cystic fibrosis, and oral health over the life course.
A Legacy for Living Systems : Gregory Bateson as Precursor to Biosemiotics
This book represents a major attempt to revise this deficiency. Scholars from ecology, biochemistry, evolutionary biology, cognitive science, anthropology and philosophy discuss how Bateson's thinking might lead to a fruitful reframing of central problems in modern science. Most important perhaps, Bateson's bioanthropology is shown to play a key role in developing the set of ideas explored in the new field of biosemiotics. The idea that organismic life is indeed basically semiotic or communicative lies at the heart of the biosemiotic approach to the study of life.The only book of its kind, this volume provides a key resource for the quickly-growing substratum of scholars in the biosciences, philosophy and medicine who are seeking an elegant new approach to exploring highly complex systems.
A History of Radionuclide Studies in the UK : 50th Anniversary of the British Nuclear Medicine Society
The British Nuclear Medicine Society celebrates its 50th Anniversary with this booklet, which reflects the research of many of the pioneers in the use of radionuclides for the diagnosis and therapy of human disease. Since 1949 there have been remarkable advances in radionuclide techniques and imaging equipment: from the first devices “home-made” in the many physics departments throughout the UK, to the sophisticated multimodality imagers now in everyday use in Nuclear Medicine. The BNMS has been instrumental in promoting the use of radionuclide techniques in the investigation of pathology by supporting and providing education, research and guidelines on the optimum use of radiation to help patients.
A History of Limb Amputation
This book traces humanity’s long experience of natural amputations due to congenital absence, disease, frostbite, toxins, domestic and wild animal trauma, and for non-medical reasons related to punitive, ritual, and legal actions, ultimately leading to the development of elective surgical amputation. While the evolution of surgical techniques forms a major chapter in the book, many ancillary problems are addressed including the control of hemorrhage and infection, the approach to pain relief, the development of suitable instruments and equipment, and the invention of prostheses, all suitably illuminated with case histories and relevant illustrations. In addition, alternative procedures designed to avoid amputation, increasingly important in the last two centuries, are debated, and factors associated with self-amputation in extremis, not rare according to press reports, are also examined. A separate chapter considers the philosophy and interpretations of society, patients, and surgeons faced with amputation, particularly before anesthesia.
A Closer Look at Antibiotic Resistance
Bacterial infections have become more difficult, and sometimes impossible, to treat due to antibiotic resistance, which occurs when bacteria develop the ability to defeat the available drugs designed to kill them. According to the Centers for Disease Control and Prevention, each year, 2 million Americans become sick with antibiotic-resistant infections, and of that, about 23,000 die. This book examines the challenges related to antibiotic resistance, the development and use of diagnostic testing to identify antibiotic resistance, the development of treatments for resistant infections, and appropriate antibiotic use.
2D Functional Nanomaterials : Synthesis, Characterization, and Applications
In 2D Functional Nanomaterials: Synthesis, Characterization, and Applications, Dr. Ganesh S. Kamble presents an authoritative overview of the most recent progress in the rational design and synthesis of 2D nanomaterials and their applications in semiconducting catalysts, biosensors, electrolysis, batteries, and solar cells. This interdisciplinary volume is a valuable resource for materials scientists, electrical engineers, nanoscientists, and solid-state physicists looking for up-to-date information on 2D heterojunction nanomaterials.



















