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الصفحة 15
الصفحة 15
An introduction to pharmacovigilance ; 2nd ed.
Designed to aid the rapid understanding of the key principles of pharmacovigilance. Packed full of examples illustrating drug safety issues it not only covers the processes involved, but the regulatory aspects and ethical and societal considerations of pharmacovigilance. Covering the basics step-by-step, this book is perfect for beginners and is essential reading for those new to drug safety departments and pharmaceutical medicine students. The second edition is thoroughly revised and updated throughout and includes a new chapter on clinical aspects of pharmacovigilance.
An introduction to generative drug discovery
Describes the state‑of‑the‑art methods and applications for de novo design of drug candidates using generative chemistry models as well as the ethical aspects of this technology. It will provide a foundation for those new to the field as well as those that may already have some experience of its utility. With contributions from scientists in both academia and industry ‘Introduction to Generative Drug Discovery’ may represent one of the earliest if not the first book to focus on this topic.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Alzheimers disease : Cellular and molecular aspects of Amyloid beta
This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy)
Alternative medicines for diabetes management : Advances in pharmacognosy and medicinal chemistry
Apart from diet and exercise, the strategic use of different classes of prescribed or non-prescribed xenobiotic compounds for the restoration of euglycemic levels in the body is well known. The ongoing rivalry between the recommended usage of allopathic medicines versus ayurvedic remedies has encouraged many researchers to focus their studies on thoroughly isolating and characterizing the extracts from different parts of plants and then evaluating their relative activities via in vitro, in vivo and in some cases clinical studies.
Allosteric Regulatory Enzymes
This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Alkaliphiles : Genetic properties and applications of enzymes
The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented. Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment. Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.
Algae and Cyanobacteria in Extreme Environments
ALGAE AND CYANOBACTRIA IN EXTREME ENVIRONMENTS is a unique collection of essays, contributed by leading scientists from around the world, devoted to algae – and some related microbes – observed in unexpected harsh habits, which it seems are an oasis or Garden of Eden for these organisms. This timely book on Extremophilic alga, including its especially impressive micrographs, may provide clues about the edges of life on Earth and possibly elsewhere in the universe. This volume is a must for students of the field of biodiversity, as well as those in Phycology, ecology and general biological research.
AI in disease detection : Advancements and applications
Discusses the integration of artificial intelligence to revolutionize disease detection approaches, with case studies of AI in disease detection as well as insight into the opportunities and challenges of AI in healthcare as a whole. The book explores a wide range of individual AI components such as computer vision, natural language processing, and machine learning as well as the development and implementation of AI systems for efficient practices in data collection, model training, and clinical validation.
AI in clinical medicine : A practical guide for healthcare professionals
A Practical Guide for Healthcare Professionals is the definitive reference book for the emerging and exciting use of AI throughout clinical medicine. AI in Clinical Medicine: A Practical Guide for Healthcare Professionals is divided into four sections. Section 1 provides readers with the basic vocabulary that they require, a framework for AI, and highlights the importance of robust AI training for physicians. Section 2 reviews foundational ideas and concepts, including the history of AI. Section 3 explores how AI is applied to specific disciplines. Section 4 describes emerging trends, and applications of AI in medicine in the future.
Agroecological transitions : From theory to practice in local participatory design
There is wide agreement on the need to change the prevalent agricultural models, given their negative impacts and their incompatibility with current societal issues. Agroecological transition has been promoted as a potential solution to the ecological, social and economic problems generated by these models. It however involves a systemic, multi-scale and transdisciplinary process. Due to this complexity, the overall picture of what farms and food systems “actually are” and “might be” may not be apparent at the individual level. Yet individuals’ knowledge and values provide complementary insights on how to proceed in deepening ecological modernisation. Expertise can also provide landmarks to be considered in that process. Because local stakeholders’ experience and skills are key resources in the adaptation and adoption of agroecological transition, new conceptual and methodological frameworks and tools have to be developed to support them in the design process of such a complex transition. This book presents feedback from the ‘Territorial Agroecological Transition in Action’- TATA-BOX research project, which was devoted to these specific issues.
Aging and the Heart : A Post-Genomic View
In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities will be undertaken.
Aging and Chronic Disorders
Aging and Chronic Disorders brings the most up-to-date answers into clear, readable focus. Focusing on the most prevalent conditions affecting older adults (diabetes, cardiovascular disease, cancer, osteoporosis, osteoarthritis, rheumatoid arthritis, low back pain, and fibromyalgia), Morewitz and Goldstein analyze disabilities and risk factors, stressors and coping strategies, treatment and rehabilitation methods, and patient education and self-management. Separate chapters are devoted to cognitive changes, psychological problems, and trends in health care utilization among seniors, and all chapters are amplified by current research findings and instructive case studies. As in their recent work.
Aesthetic Surgery of the Facial Mosaic
This authoritative reference book assembles the experience of an international faculty of authors, each of whom has performed several thousand facelifts, i.e. procedures to rejuvenate and harmonize the human face. All procedures in this regard are covered and the text is accompanied by extensive artwork and photographs. The authors share their experience, including tips and tricks, as well as ways to avoid complications and pitfalls. Special emphasis is given to the concept of looking at the face as a mosaic, i.e. treating its individual parts in a harmonic way and maintaining mimic units. Combining different methods.
Advances in Targeted Cancer Therapy
This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed.
Advances in Radiation Oncology in Lung Cancer
This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state of the art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Advances in Microbiology, Infectious Diseases and Public Health ; Vol.15
Focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention.
Advances in Healthcare Technology : Shaping the Future of Medical Care
This book describes valued contributions of technology for improving hospital and home healthcare, and gives a perspective on how they will influence critical aspects of future medical care. It provides an overview and discussion of trends, presents the state-of-the-art of important research areas, and highlights recent breakthrough results in selected fields, giving an outlook on game-changing developments in the coming decades.
Advances in flavonoids for human health and prevention of diseases
In response to the recent upsurge of interest in the therapeutic potential of medicinal plants, with their promising phenolic compounds, this new book offers an important overview of advances in the applications of flavonoids for health. The book explores the nutritional and pharmacological properties of polyphenols and flavonoids, including their ability to prevent the start and development of diseases and how they aid in the management of several chronic pathological illnesses, including cancer, diabetes, cardiovascular disease, neuro-degenerative illness and aging, pregnancy-induced disorders, and others. Also discussed in depth are the properties, classes, and degrees that formulate a phenolic compound and which subsequently supports the development of drugs/products with health benefits.
