الصفحة 130
الصفحة 130
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Cambridge and Vienna : Frank P. Ramsey and the Vienna Circle
The Institute Vienna Circle held a conference in 2003, Cambridge and Vienna: Frank P. Ramsey and the Vienna Circle, to commemorate the philosophical and scientific work of Frank Plumpton Ramsey (1903-1930). This Ramsey conference provided historical and biographical perspectives on one of the most gifted thinkers of the Twentieth Century.
Calvinisms First Battleground : Conflict and Reform in the Pays de Vaud, 1528-1559
A specifically Calvinist identity and theology emerged out of two key conflicts in the region: first, the fight to turn away from Catholic practices and traditions a population that had been forced to convert to Protestantism by the Bernese after their conquest of Vaud in 1536; second, the struggle against the Zwinglian political and theological ideas that dominated the Swiss Confederation and differed from the Calvinists' understanding of ecclesiastical discipline, the Eucharist, and predestination. The Pays de Vaud was central to this struggle, for it was subject politically to Zwinglian, German-speaking Bern, but many of its ministers were more strongly influenced by Calvin. Calvin himself was initially excited about the prospects for reform in the region, but frustrations with the Swiss led him and the Genevans increasingly to focus their efforts on France.
Calixarenes in the Nanoworld
Calixarenes have been widely exploited in all areas of supramolecular chemistry over the past three decades and many recent developments have concerned their applications in the production of chemical entities with the dimensions of nanometres, as in "nanochemistry".Calixarenes in the Nanoworld Relates calixarenes to nanochemistry – key information for industries engaged in the production of high-tech materials. Provides a timely review of both what is known and the exciting prospects provided by calixarenes, Contains several review articles which define the importance of calixarenes as reagents in nanochemistry.
Calibration Techniques in Nyquist A/D Converters
It is shown that in order to achieve high speed and high accuracy at high power efficiency, calibration is required. Calibration reduces the overall power consumption by using the available digital processing capability to relax the demands on critical power hungry analog components. Several calibration techniques are analyzed. The calibration techniques presented in this book are applicable to other analog-to-digital systems, such as those applied in integrated receivers. Further refinements will allow using analog components with less accuracy, which will then be compensated by digital signal processing. The presented methods allow implementing this without introducing a speed or power penalty.
Calibrating the Cosmos : How Cosmology Explains Our Big Bang Universe
Calibrating the Cosmos describes hard science, but is gently written. It explains in clear, non-mathematical language the measurements and the interpretation of the resulting data that have led to the current understanding of the origin, evolution and properties of our expanding Big Bang universe. Many people have a sketchy idea of the work of cosmologists, but Professor Levin’s experience in teaching both scientific and liberal arts students has enabled him to impart much of our current thinking without resorting to difficult mathematics. Theoretical concepts are emphasized, in particular the symmetries of homogeneity and isotropy enjoyed by our universe on the largest scales, how these symmetries lead to only one quantity being needed to describe the growth of the universe from its infancy to the present time, and how the so-called parameters of the universe are the ingredients used to construct the model universes to which ours – the real thing – is compared.
Calculus of one variable
Aimed at first-year undergraduates in mathematics and the physical sciences, the only prerequisites are basic algebra, coordinate geometry and the beginnings of differentiation as covered in school. The transition from school to university mathematics is addressed by means of a systematic development of important classes of techniques, and through careful discussion of the basic definitions and some of the theorems of calculus, with proofs where appropriate, but stopping short of the rigour involved in Real Analysis.The influence of technology on the learning and teaching of mathematics is recognised through the use of the computer algebra and graphical package MAPLE to illustrate many of the ideas.
Calculus and mechanics on two-point homogenous riemannian spaces
The present monograph gives a short and concise introduction to classical and quantum mechanics on two-point homogenous Riemannian spaces, with empahsis on spaces with constant curvature. Chapter 1-4 provide the basic notations from differential geometry for studying two-body dynamics in these spaces. Chapter 5 deals with the problem of finding explicitly invariant expressions for the two-body quantum Hamiltonian. Chapter 6 addresses one-body problems in a central potential. Chapter 7 studies the classical counterpart of the quantum system of chapter 5. Chapter 8 investigates some applications in the quantum realm, namely for the coulomb and oscillator potentials.
Calcium in Human Health
Calcium performs diverse biological functions in the human body and is a micronutrient essential to human health and well-being. It serves as a second messenger for nearly every biological process, stabilizes many proteins, and in deficient amounts is associated with a large number diseases and disorders. In Calcium in Human Health, a panel of highly respected researchers and clinical practitioners comprehensively reviews the state of our knowledge concerning this ubiquitous micronutrient, not only demonstrating its importance to human health, but also defining its many complex roles.
C*-algebras and Elliptic Theory II
This book consists of a collection of original, refereed research and expository articles on elliptic aspects of geometric analysis on manifolds, including singular, foliated and non-commutative spaces. There are contributions from leading specialists, and the book maintains a reasonable balance between research, expository and mixed papers.
C*-algebras and Elliptic Theory
This volume contains the proceedings of the conference on "C*-algebras and Elliptic Theory" held in Bedlewo, Poland, in February 2004. It consists of original research papers and expository articles focussing on index theory and topology of manifolds.The collection offers a cross-section of significant recent advances in several fields, the main subject being K-theory (of C*-algebras, equivariant K-theory). A number of papers is related to the index theory of pseudodifferential operators on singular manifolds (with boundaries, corners) or open manifolds. Further topics are Hopf cyclic cohomology, geometry of foliations, residue theory, Fredholm pairs and others.
Business Writing For Dummies
This friendly guide equips you with a step-by-step method for planning what to say and how to say it in writing. This sytem empowers you to handle every writing challenge with confidence, from emails to proposals, reports to resumes, presentations to video scripts, blogs to social posts, websites to books. Discover down-to-earth techniques for sharpening your language and correcting your own writing problems. Learn how to adapt content, tone and style for each medium and audience. And learn to use every message you write to build better relationships and solve problems, while getting to the “yes” you want.
Business processes : An archival science approach to collaborative decision making, records, and knowledge management
Collaborative decision making processes are a form of communication inside organizations. Their functioning can teach lessons for the design of electronic office systems. Those processes are open ended and therefore decide themselves on their form. Like oral deliberations which cannot be modelled in advance any open ended communication process needs means for common control over the further advancement and the ending of the process.The book is a reworked English version of a thesis for the official qualification for university professorship accepted by the German University of Administrative Sciences Speyer. Germany.
Business Ethics of Innovation
Firms that operate in a market economy often depend upon innovations in order to achieve competitive advantages that sustainably secure their survival. Business ethics is thus largely concerned with questions about the decisional freedoms involved in innovation processes. Innovations oftentimes raise novel questions about the role of the state or the structure of society. Business ethics needs to provide a framework for balancing the different perspectives, values, and interests at stake. This balance must be achieved at the level of the firm in order to facilitate adequate long term decisions, but it should also be sought at higher, including regulatory, levels. Achieving this balance will require an ethical framework for entrepreneurial action.
Business Ethics : The Ethical Revolution of Minority Shareholders
The empirical part of the book presents four cases of US, French and Israeli companies, most of them in high-tech, in which the minority shareholders lose almost all of their investments. The cases are based on current events and try to find the common aspects and basic rules that govern the wrongdoing to minority shareholders.The book concludes that once the minority shareholders, who are ultimately all of us, are assisted by the new vehicles of Ethics, and are properly organized, motivated and conscious of their strengths, they will be able to win their fight and safeguard their interests.
Buried Waste in the Seabed – Acoustic Imaging and Bio-Toxicity : Results from the European SITAR Project
Buried waste on the seabed is a major source of pollution. But, very often, waste sites are not known until a serious problem occurs, or are not adequately mapped. Recent examples around Europe include WWI and WWII ammunition dump sites (e.g. Beufort Dyke in the UK), dumped nuclear submarines in the Arctic Seas, clandestine or hidden toxic-waste in the Baltic Sea and the North Sea.. Even if properly documented, waste sites evolve with time (dumped material can move with currents and tides, especially on a scale of decades; toxic-material barrels can corrode and leak). This book shows the results of a concerted EU-funded effort to tackle this problem and find innovative ways to identify and map toxic waste sites ona the seabed, whether they have been covered with sediments or not. These results are applicable to any region on the seabed in the entire world.
Bulk Metallic Glasses : An Overview
Bulk Metallic Glasses explores an emerging field of materials known as bulk metallic glasses. It summarizes the rapid development of these materials over the last decade and includes documentation on diverse applications of bulk metallic glasses; from structural applications to microcomponents. Some of the applications covered are pressure sensors, microgears for motors, magnetic cores for power supplies, and nano-dies for replacing next generation DVDs. The chapters cover current theories and recent research including an atomistic theory of local topological fluctuations, atomistic simulations, and unique microstructures of these amorphous materials. Other topics include glass formation, glass forming ability, and the underlying mechanisms and physical insights of these criteria. The mechanical deformation of bulk metallic glasses, fatigue, fracture, and corrosion behaviors of these materials are also reviewed.
Buildings : Theory and Applications
This book treats Jacques Tits's beautiful theory of buildings, making that theory accessible to readers with minimal background. It includes all the material of the earlier book Buildings by the second-named author, published by Springer-Verlag in 1989, which gave an introduction to buildings from the classical (simplicial) point of view. This new book also includes two other approaches to buildings, which nicely complement the simplicial approach: On the one hand, buildings may be viewed as abstract sets of chambers with a Weyl-group-valued distance function; this point of view has become increasingly important in the theory and applications of buildings. On the other hand, buildings may be viewed as metric spaces. Beginners can still use parts of the new book as a friendly introduction to buildings, but the book also contains valuable material for the active researcher.
Building the Inclusive City : Governance, Access, and the Urban Transformation of Dubai
This book is an anthropological urban study of the Emirate of Dubai, its institutions, and their evolution. It provides a contemporary history of disability in city planning from a non-Western perspective and explores the cultural context for its positioning. Three insights inform the author’s approach. First, disability research, much like other urban or social issues, must be situated in a particular place
Building the Foundation : Whole Numbers in the Primary Grades : The 23rd ICMI Study
This twenty-third ICMI Study addresses for the first time mathematics teaching and learning in the primary school (and pre-school) setting, while also taking international perspectives, socio-cultural diversity and institutional constraints into account. One of the main challenges of designing the first ICMI primary school study of this kind is the complex nature of mathematics at the early level. Accordingly, a focus area that is central to the discussion was chosen, together with a number of related questions. The broad area of Whole Number Arithmetic (WNA), including operations and relations and arithmetic word problems, forms the core content of all primary mathematics curricula. this study presents a meta-level analysis and synthesis of what is currently known about WNA, providing a useful base from which to gauge gaps and shortcomings, as well as an opportunity to learn from the practices of different countries and contexts.
