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Factorial design plays a fundamental role in efficient and economic experimentation with multiple input variables and is extremely popular in various fields of application, including engineering, agriculture, medicine and life sciences. Factorial experiments are often used in case studies in quality management and Design for Six Sigma (DFSS).Factorial design plays a fundamental role in efficient and economic experimentation with multiple input variables and is extremely popular in various fields of application, including engineering, agriculture, medicine and life sciences. Factorial experiments are often used in case studies in quality management and Design for Six Sigma (DFSS).