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constitutethe proceedings of the 2nd International Conference on Natural Computation (ICNC 2006), jointly held with the 3rd International Conference on Fuzzy Systems and Knowledge Discovery, ICNC-FSKD 2006 featured the most up-to-date research results in com- tational algorithms inspired from nature, including biological, ecological, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide rangeof techniques and methods arebeing studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cro- fertilization over these exciting and yet closely-related areas, which had a s- nifcant impact on the advancement of these important technologies. Specifc areas included neural computation, quantum computation, evolutionarycom- tation, DNA computation, fuzzy computation, granular computation, artifcial life, etc., with innovative applications to knowledge discovery, fnance, ope- tions research, and more. In addition to the large number of submitted papers, we were blessed with the presence of six renowned keynote speakers.