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Questions-and-answers style, and each question is answered according to the hierarchy of evidence. At the end of each answer, an interpretation of the included systematic reviews, randomized clinical trials, or other studies is summarized and critically reviewed to give a better understanding of the evidence. It covers a wide range of clinical topics, such as the treatment of Class II and Class III malocclusion, molar distalization, impacted canines, maxillary expansion, and temporary anchorage devices. Valuable material is provided on root resorption, white spot lesions, and orthodontic retention.