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Volume 1 examines the participation of innate immunity in diseases such as infections by viruses, cancer, or parasites. Specifically, this volume discusses innate immunity as it relates to chronic HIV infection, type 2 diabetes, and SARS-CoV-2, as well as its relationship with vitamin D. The dual role of neutrophils in cancer development and the plasticity of natural killer cells are investigated. Also, the immune response to infections from helminth and Toxoplasma gondii are described.