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Peptic ulcers are a common clinical presentation in the Middle East and often lead to the expenditure of millions of healthcare dollars. They are a break in the mucosal barrier of the stomach lining that penetrates through the muscularis mucosa. It is important to understand this disease process is both preventable and treatable, the role of clinical laboratory in diagnosis, Understanding how patient are treated differently depending on the etiology of their gastric ulcer, and prevent being a victim of this disease.