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There has been a growing interest in vitamin D during the last decades, which has boosted an increasing number of scientific papers on this topic. Vitamin D has a significant role in calcium homeostasis and metabolism, vitamin D deficiency is a worldwide health problem that affects not only musculoskeletal health but also a wide range of acute and chronic diseases, There is potentially a great upside to increasing the vitamin D status of children and adults worldwide for improving musculoskeletal health and reducing the risk of chronic illnesses, including some cancers, autoimmune diseases, infectious diseases, type 2 diabetes mellitus, neurocognitive disorders, and mortality. In addition, there are many evidences about the correlation between the vit.D and the levels of quality of life. Recently, taking of vit.D3 become in the guideline for cure and help the treatment of COVID-19 epidemic.