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Pain is defined as an unpleasant sensory and emotional experience that is associated with actual or potential tissue damage or described in terms of such damage. It is subjective and considered an important physiological mechanism by which humans prevent themselves from developing tissue injury. However, pain patients do not respond to treatment in the same way, which makes it challenging to issue a consistent treatment for all pain conditions. Excessive pain can markedly increase psychological health problems and decrease health‐related quality of life; therefore, pain should be managed appropriately by analgesics. Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications. Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined. Pain severities as well as responses to analgesics, can also be very variable among sufferer.