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The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and also provides the basis for existing and fixture therapeutic strategies targeting MIRRs. The reviews assembled in this book detail the prog-ress in defining and controlling the spatiotemporal organization of key events in immune cell activation. An improved understanding of MIRR-mediated signaling has numerous potential practical applications, fi-om the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes.