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Tissue Mechanics, Second Edition is about the mechanics of tissues for use at the advanced undergraduate level or above. Tissues transmit mechanical loads just like bridges and building structures. Not only do they transmit loads, but also they adapt their own structures so that the structures will transmit the mechanical loads more effectively, unlike bridges and building structures. The structures of living tissues are continually changing due to growth and response to the tissue environment, including the mechanical environment. The objective of this text is to describe the nature of the composite components of a tissue, the cellular processes that produce these constituents, the assembly of the constituents into a hierarchical structure, and the behavior of the tissue’s composite structure in the adaptation to its mechanical environment. A tissue’s mechanical environment is the history of mechanical loading experienced by the tissue in some reference time period, like a day.