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978-1-59745-080-5

The Serotonin Receptors

Publication Date: 2006

ISBN: 978-1-59745-080-5

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The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice.


Subject: Medicine, Nervous System, biology, brain, dementia, depression, drug, drug discovery, genome, molecular biology, neuroanatomy, neurotransmitter, pharmacology, physiology, schizophrenia, serotonin